By W.H.R. Lumsden, R. Muller, J.R. Baker (Eds.)
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Additional resources for Advances in Parasitology, Vol. 17
Giardia trophozoites have been found more commonly in individuals suffering from diarrhoea than in those without intestinal disease (Ormiston e t a / . , 1942; Shrivastav, 1960; Antia e t a / . , 1969; Veazie, 1969). Diarrhoea occurs more frequently in parasitized than in non-parasitized individuals (Wanner et a / . , 1960). , 1942; Brown, E. , 1948; Antia et a / . , 1966; Alp and Hislop, 1969). Rendtorff (1954) demonstrated that feeding Giardia cysts caused diarrhoea. Malabsorption due to Giardia infection has been reported by a number of workers.
1967). GIARDIA A N D G I A R D I A S I S 21 The existence of structural or functional changes in the parasitized small intestine has become a subject of interest to investigators searching for an explanation of the mechanism of Giardia pathogenesis. A broad spectrum of such changes has been observed, ranging from acute inflammatory changes with epithelial cell destruction to thickening and shortening of the villi. Descriptions of such changes may be found in the papers of Zamcheck et a/. (1963), Yardley e t a / .
Some physicians use it empirically, in the absence of demonstrated organisms, where giardiasis is strongly suspected. , 1972) no more than 71 % were cured. Its adverse effects include frequent nausea and headache, occasional vomiting and diarrhoea; and alcohol is contraindicated for 24 hours after its administration. , 1974). Its use is thus contraindicated in pregnant women (Medical Letter, 1975). It might also be wise to limit its use generally to treating those infections that fail to respond to other chemotherapy.