By Karsten Schrör
Written through a number one specialist on Aspirin-related examine, this can be the main accomplished treatise at the pharmacological results and scientific functions of 1 of the main winning medications ever.
The textual content is written with a large viewers in brain, and to be without problems comprehensible for clinicians, pharmacists, biomedical researchers and pharmacologists alike.
This moment, thoroughly revised version includes the most recent result of scientific and pharmacological study on Acetylsalicylic acid, addressing the a number of pharmacological homes of this well-known drug with a balanced view on their translation into scientific perform, together with prevention from cardiovascular illnesses and colorectal cancer.
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1956) Prevention of coronary and cerebral thrombosis. Mississippi Valley Medicinal Journal, 78, 213–215. C. L. (1991) The Aspirin Wars, Alfred A. Knopf, New York. A. A. (1988) Aspirin in cardiovascular disease. Drugs, 35, 154–176. 60 Antiplatelet Trialists Collaboration (1988) Secondary prevention of vascular disease by prolonged antiplatelet treatment. British Medical Journal, 296, 320–331. 61 ISIS-2 (1988) Randomized trial of intravenous streptokinase, oral aspirin, both or neither among 17,187 cases of suspected acute myocardial infarction.
1988 Publication of the ﬁrst clinical ﬁndings of a relationship between aspirin intake and prevention of colon cancer by Gabriel Kune and colleagues from Melbourne. In this retrospective, exploratory case–control study, regular (daily) use of aspirin reduced the risk of (incident) colon cancer by 40%. These ﬁndings were later conﬁrmed and extended by Michael Thun and colleagues (1991) in a large prospective epidemiological trial (CPS-II Study) in the United States. 1988–1989 Publication of the ﬁrst two prospective, placebo-controlled long-term trials on primary prevention of myocardial infarctions in apparently healthy men in the United States (USPHS) and the United Kingdom (BMDS), respectively.
3). It is no more used for systemic internal administration because of its unpleasant, sweetish taste and irritation of the stomach mucosa. 7 Chemical structures of selected salicylates. 2) and acetaminophen (paracetamol). Nevertheless, salicylate is still being used as an external medication, for example, in ointments because of its antiseptic and keratolytic properties. 1). Salicylate shows a peculiar physicochemical behavior because of the formation of a ring structure by hydrogen bridging. 8) but not with its m- and p-analogues.